The activation of quarterback Peyton Manning from the PUP list meant that either Curtis Painter or Dan Orlovsky would be losing his job, unless the Colts planned to keep four quarterbacks on the active roster.
The odd man out is Orlovsky.
The Colts sent the man who once ran out of the end zone out of the building on Saturday, as 27 players were released to trim the roster to 53.
The players who were cut are: defensive back Al Afalava, punter Travis Baltz, receiver Chris Brooks, defensive end John Chick, linebacker Chris Colasanti, guard Kyle DeVan, tight end Tyson DeVree, defensive tackle John Gill, receiver David Gilreath, defensive back Michael Hamlin, defensive tackle Tommie Harris, running back Javarris James, defensive back Brandon King, offensive lineman Jake Kirkpatrick, tight end Michael Matthews, defensive tackle Ricardo Mathews, guard Jacques McClendon, receiver Larrone Moore, linebacker Kerry Neal, defensive tackle Ollie Ogbu, receiver Taj Smith, tackle Mike Tepper, tackle Michael Toudouze, linebacker Nate Triplett, linebacker Vuna Tuihalamaka, and receiver Marshall Williams.