The Chargers now have 11 players on injured reserve.
Vaughn suffered a groin injury in warmups before the Chargers 34-24 win in Pittsburgh last week while Stuckey re-injured a hamstring during the game.
To fill their spots on the roster, the Chargers re-signed running back Curtis Brinkley and linebacker Gary Guyton. Brinkley appeared in seven games for the Chargers and made one start before being released on Nov. 29.
Guyton spent his first four seasons playing for the New England Patriots. He spent training camp with the Miami Dolphins before being released.
The Chargers also released receiver Kashif Moore from the practice squad and re-signed defensive end Logan Harrell.