Saffold was hurt on the Rams’ second offensive snap, a pass play.
Formerly the Rams’ left tackle, Saffold has moved to the right side with Jake Long now in the fold.
Saffold, 25, is in his fourth NFL season. He played collegiately at Indiana.
UPDATE 10:34 p.m. ET: Per Nick Wagoner of ESPN.com, Fisher indicated in a radio interview that Saffold’s injury is not serious, with X-rays coming back negative.