Defensive end Jason Pierre-Paul (illness) is also questionable after missing practice for a second straight day.
Pierre-Paul has 15 tackles and one sack this season. He missed much of the offseason with back surgery.
The Giants have officially ruled out Wilson and cornerback Jayron Hosley (hamstring) for Monday. Tight end Adrien Robinson (foot) and safety Cooper Taylor (shoulder) are questionable. Center David Baas (neck) and cornerback Terrell Thomas (knee) are probable.