A 17-point burst in the final 7:12 of the second quarter gave the Bills a 20-10 halftime lead at Jacksonville on Sunday afternoon.
Bills quarterback EJ Manuel has rushed for a touchdown and thrown for another for Buffalo, which trailed 10-3 early in the second quarter before turning it on.
Manuel threw for 113 yards and rushed for 31 yards in the first half. Bills tailbacks Fred Jackson and C.J. Spiller added a combined 97 yards rushing on 15 carries in the first two quarters.
Jaguars quarterback Chad Henne threw for 129 yards and touchdown in the first half. Jacksonville committed a pair of turnovers in the first 30 minutes, both of which led to Buffalo field goals.