The Colts lead the Broncos 10-7 at halftime in a game overshadowed by injuries.
Denver lost quarterback Trevor Siemian, who will not return with a left shoulder injury. Colts running back Frank Gore limped off with a left knee and quad injury, though he returned to start the second half. Colts tight end Brandon Williams was transported to a local hospital with a head injury.
Kenny Moore got the Colts off to a good start with an interception of Siemian, and Indianapolis used the short field for a 7-0 lead. Quarterback Jacoby Brissett capped off the seven-play, 50-yard drive with a 7-yard touchdown run.
Adam Vinatieri added a 45-yard field goal with 6:33 remaining in the second quarter for a 10-0 Colts lead.
But Brock Osweiler has brought the Broncos back, scoring on an 18-yard run after the most spectacular play of the night -- a 30-yard touchdown pass from Osweiler to Devontae Booker, who hurdled Colts safety Clayton Geathers -- was negated by a holding penalty on Garett Bolles. Bolles leads the league with nine holding penalties.
The difference is a missed 40-yard field goal by Broncos kicker Brandon McManus, which followed a delay of game penalty.
Brissett has gone 7-for-11 for 82 yards, and Osweiler is 7-for-11 for 74 yards.
C.J. Anderson has nine carries for 47 yards, and Demaryius Thomas has five catches for 69 yards.
Denver has outgained Indianapolis 206 yards to 139 yards.