The Chargers waited 12 weeks for Vincent Jackson to return and take part of two plays.
Jackson left the game quickly after injuring his calf, then was seen stretching it out on the sideline. After the Chargers initially said he would return, Jackson was ruled out for the rest of the game.
San Diego leads 13-7 early despite the injury to Jackson and tight end Antonio Gates hobbling around the field. Peyton Manning has been picked off twice, including a pick six by Chargers linebacker Kevin Burnett.
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