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Kevin Kolb, Joe Staley leave game in Arizona

Cardinals quarterback Kevin Kolb fumbles after getting hit by Jarret Johnson of the Ravens in Baltimore

Arizona Cardinals quarterback Kevin Kolb fumbles the football after getting hit from behind by Jarret Johnson of the Baltimore Ravens in the first quarter of their NFL football game in Baltimore, Maryland October 30, 2011. REUTERS/Joe Giza (UNITED STATES - Tags: SPORT FOOTBALL)

REUTERS

It’s John Skelton time once again in Arizona.

Kevin Kolb left Sunday’s game in the first quarter after taking a hit to the head as he was getting tackled from behind. John Skelton has entered the game.

49ers left tackle Joe Staley also left with a head injury and is out for the game.