Browns safety Ibraheim Campbell was carted off the field after getting hurt on the second play of the game, a 12-yard run by Saints running back Alvin Kamara. Campbell has a concussion, the Browns announced.
Rookie Jabrill Peppers, a first-round choice, replaced Campbell.
Campbell, a fourth-round choice in 2015, started seven games at strong safety last season. He split the role with Derrick Kindred, a fourth-round choice in 2016.
Campbell made 43 tackles last season.