It took the Titans almost 50 minutes, but they finally scored their first touchdown of the night.
DeMarco Murray scored on a 3-yard run with 10:01 remaining in the fourth quarter, giving the Titans a 22-19 lead after trailing by 10 points in the third quarter.
Murray has 12 carries for 40 yards, despite a tight hamstring, and Derrick Henry has 13 carries for 43 yards.
Marcus Mariota has completed 20 of 29 passes for 232 yards with the interception John Simon returned for a touchdown.
The Colts did not have a first down in the third quarter.