Titans rookie tight end Jonnu Smith was carted off in the third quarter after grabbing his right knee.
Smith’s leg was rolled from behind during a kickoff return following a Patriots’ touchdown that gave New England a 28-7 lead.
He appeared in considerable pain as trainers tended to him on the field.
Smith has one catch for 4 yards.
The Titans announced right tackle Jack Conklin will not return after leaving in the first quarter with a knee injury.