The Colts have outgained Washington 162 yards to 56 yards so far, dominating the first quarter and a half.
More importantly, they lead 14-3 on the scoreboard.
Washington got a 49-yard Dustin Hopkins field goal to draw within 7-3 early in the second quarter.
But the Colts tacked on another touchdown on an 8-yard run by Nyheim Hines, going 75 yards on eight plays.
Luck has completed 10 of 14 passes for 95 yards with a touchdown and an interception.
Alex Smith is 5-for-8 for only 35 yards.