Tight end Darren Fells had two second-half touchdowns on his only two catches as the Texans scored 37 second-half points after trailing 17-16 at halftime. Fells’ scores covered 8 and 12 yards.
Watson completed 28 of 33 passes for 426 yards with five touchdowns and no interceptions.
Fuller had a career-high 217 yards on 14 catches to go with his career-best three scores.
The Texans ended up with 592 yards, with 365 coming in the second half. They scored on all five second-half possessions, getting four touchdowns and a field goal.
Ryan finished 32-of-46 for 330 yards with three touchdowns and an interception.