Christian Wilkins‘ day lasted all of two plays and 33 seconds.
Officials ejected the Dolphins defensive lineman for throwing a punch at Bills offensive lineman Cody Ford.
It came on an incomplete pass Josh Allen intended for Cole Beasley. The 15-yard penalty gave the Bills a first down instead of third-and-2.
The drive ended with a 39-yard field goal by Stephen Hauschka, giving Buffalo a 3-0 lead.
Wilkins arguably is Miami’s best defensive player.
The 13th overall choice made 18 tackles and a pass breakup in five games before Sunday.