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Report: Christian McCaffrey is expected to miss multiple weeks

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Mike Florio and Chris Simms draft the biggest surprises from Week 2, including more Ravens domination, the Jaguars keeping it close vs. Titans and Leonard Fournette's big game with the Buccaneers.

Panthers running back Christian McCaffrey appears to have suffered a more serious ankle injury than he initially believed.

McCaffrey said after Sunday’s game that his ankle was going to be fine, but he is actually expected to miss “multiple weeks,” Adam Schefter of ESPN reports.

That’s a big blow to the Panthers, who signed McCaffrey to a four-year, $64 million contract this offseason. Last year McCaffrey topped 1,000 yards both rushing and receiving, becoming just the third player in NFL history to do so.

Through two games this season, McCaffrey has 41 carries for 156 yards and a league-leading four rushing touchdowns. He also has seven catches for 67 yards.