Williams has a hamstring injury and Bosa has triceps and knee injuries that had his status uncertain. The Chargers listed both players as questionable.
The Saints will have tight end Jared Cook (groin). He was listed as questionable with limited practices all week. Defensive end Marcus Davenport (toe) and cornerback Marshon Lattimore (hamstring) also will play.
The team’s inactives are cornerback Janoris Jenkins (shoulder), cornerback Justin Hardee (hamstring), receiver Deonte Harris (hamstring), receiver Michael Thomas, offensive lineman Ethan Greenidge, tight end Adam Trautman and defensive lineman Malcolm Roach.