The Broncos got off to a slow start and trailed early before they found their groove. Denver then reeled off 23 consecutive points to roll to a 23-13 win.
The Jaguars’ final touchdown came on a 102-yard kickoff return by Jamal Agnew.
Teddy Bridgewater went 26-of-34 for 328 yards and two touchdowns. Tim Patrick caught a 12-yard touchdown, and Noah Fant had a 14-yarder for a score.
Courtland Sutton had nine catches for 159 yards.
Brandon McManus kicked field goals of 32, 46 and 40 yards.
Rookie Trevor Lawrence was 14-of-33 for 118 yards with a touchdown and two interceptions. Marvin Jones caught a 25-yard touchdown with 9:21 remaining in the first quarter as the Jaguars took a brief lead.
But the Broncos were too much for the Jaguars, outgaining them 398 to 189.