Rams running back Darrell Henderson played 40 of 59 offensive snaps Sunday, exiting with a rib injury in the fourth quarter.
Rams coach Sean McVay said Monday that Henderson is dealing with a rib cartilage injury.
The team is hopeful Henderson can play Sunday, but his status might remain uncertain until Friday, McVay said. Henderson will not practice early in the week.
Michel, who arrived in an Aug. 25 trade from New England, had 10 carries for 46 yards against the Colts after getting only one carry for 2 yards in three snaps in the opener.
In two games, Henderson has 33 touches for 169 yards and two touchdowns.