The Colts have won two in a row and four of their last five to get back to .500 at 5-5.
The Colts had three sacks of Lawrence, the final a combination of Buckner and Dayo Odeyingbo after the Jaguars had reached the Indianapolis 46. Lawrence finished 16-of-35 for 162 yards.
The Jaguars ran for 179 yards with Jamal Agnew taking three carries for 79 yards, including a 66-yard touchdown run. James Robinson had 12 carries for 57 yards and a touchdown, and Lawrence added 33 yards on five carries.
The Colts gained only 295 yards.
Jonathan Taylor rushed for 116 yards and a touchdown on 21 carries. He had 10 carries for 93 yards in the first quarter.