The Saints finally are on the scoreboard.
New Orleans has 319 yards, but it took the team until the fourth quarter to get in the end zone. Mark Ingram scored on a 5-yard run with 12:31 remaining.
The 10-play, 89-yard drive had drawn the Saints to within 13-7 of the Panthers.
Mayfield is 10-of-21 for 143 yards and a touchdown.
The Saints had a field goal blocked at the end of the second quarter and Wil Lutz missed a 48-yard try wide right with 7:16 remaining in the third quarter.