The 49ers are pulling away now.
The Cardinals blitzed, and the 49ers beat it with a quick throw to Aiyuk, who broke the tackle of Marco Wilson on his way to the end zone.
Aiyuk’s first touchdown covered 7 yards.
Garoppolo has completed 18 of 27 passes for 189 yards with three touchdowns.
The 49ers are beating up Cardinals quarterback Colt McCoy, who entered with a knee injury. McCoy had Nick Bosa inadvertently step on his hand and Kevin Givens drilled McCoy on a sack late in the third quarter. McCoy has taken two sacks and seven hits.