Monday Night Football: 49ers blow out Cardinals 38-10 as Jimmy Garoppolo throws four TDs

San Francisco 49ers v Arizona Cardinals
Getty Images

The NFL has touted all the close games it has had this season. Monday night was not one of them.

The 49ers dominated the Cardinals, winning 38-10 and leaving the scarlet red and metallic gold-clad fans in Mexico City happy. The 49ers moved to 6-4 and into first place in the NFC West with a tiebreaker advantage over Seattle, and the Cardinals fell to 4-7.

San Francisco outscored Arizona 21-0 in the second half, and by the middle of the fourth quarter, Trace McSorley and Brock Purdy were playing quarterback with the game out of hand. It was an embarrassing finish for the Cardinals as some of their defensive players made a business decision not to try to tackle George Kittle on the 49ers’ final touchdown.

The 49ers gained 387 yards.

Jimmy Garoppolo completed 20 of 29 passes for 228 yards and four touchdowns.

Kittle and Brandon Aiyuk both scored two touchdowns, and Deebo Samuel had the other. Kittle caught four passes for 84 yards and Aiyuk two for 20. Samuel had three carries for 37 yards and a touchdown and seven catches for 57 yards. Christian McCaffrey contributed seven carries for 39 yards and seven receptions for 67 yards.

Colt McCoy, who entered with a knee injury, took a beating in the second half. Nick Bosa inadvertently stepped on McCoy’s hand, and McCoy took a hard sack from Kevin Givens and a late hit from behind from Bosa, who was penalized for roughing the passer.

McCoy, who was playing in place of injured starter Kyler Murray, went 24-of-34 for 218 yards and an interception. The 49ers also intercepted McSorley as they had three sacks, eight quarterback hits and two takeaways.

Greg Dortch had nine catches for 103 yards after replacing Rondale Moore, who played only two plays before leaving with a groin injury.

37 responses to “Monday Night Football: 49ers blow out Cardinals 38-10 as Jimmy Garoppolo throws four TDs

  1. Career hi 4 TDs for Jimmy G. Offense has all its weapons firing. I see them possibly ending 6-1 in the last seven, based on their sked: three straight home games, Saints, Dolphins, Bucs….at Seattle (OK, they always play bad there), Washington at home, Raiders in Vegas, and Cards at home.

  2. The Niners are finally deploying the full use of their arsenal – albeit against a struggling team – but it’s fun to watch nonetheless.

    ¡Viva los Niners!

  3. Int. Jimmy G. is squirreling away all his critical games blowing picks for use in the playoffs — when it really counts! 🤗

  4. Arizona still trying to win games with that college coach running his college playbook…Not happening

  5. Mr. Cheese says:
    November 21, 2022 at 11:36 pm
    9er fans do you do still want Aaron Rodgers…asking for a friend

    —————-

    Tell your friend 49ers would be much more dominant with Rodgers. Let’s wait to see how Jimmy G finishes the season?

  6. Reworking Jimmy G’g contract was a win/win for both of them. San Fran made a smart move and J.G. knew if he didn’t take a haircut he would have made even less on the open market. I’m glad to see it’s working out for both of them. (4 td’s… come on now).

  7. Lol. Cardinals fans thought that they found something in their 36 year old backup quarterback.

  8. Ha, Mr. Cheese, please give our regards to your best buddy Aaron! Both of you stop by for a nice, hot mug of 7-11 crusty, overheated nacho sauce next time you’re in town; it’ll be the perfect backdrop for playing your special highlight reel we’re excitedly assembling.

  9. All he does is win games. I told all of you they would be fools to trade Jimmi G. He’s elite

  10. Arizona still trying to win games with that college coach running his college playbook…Not happening

    Try winning with a high school OC using a JV playbook! Oh Canada!

  11. austinspencer says:
    November 21, 2022 at 11:34 pm
    Chiefs, Bills, Ravens. Eagles, 49ers, Cowboys. Best 6 teams in NFL.
    —————————————————————-
    It has never truly mattered, nor will it ever truly matter who the best teams are in November. I would even guess most of us didn’t have the Bengals in our “best 6 teams in NFL” at this time last year yet they went to the SB. Also, key injuries at anytime during the season can be the great equalizer. Just sayin’.

  12. Murray has now missed multiple games in-a-row due to a hamstring that didn’t require him to miss any time in the game where he supposedly hurt it. Good luck building a team around a guy who won’t play unless he’s feeling fully 100%.

  13. MortimerInMiami says:
    November 21, 2022 at 11:33 pm
    49ers are the best team in the NFC, yes its true Eagle fans.
    ————————————
    They are 1-1 against teams that currently have a record over .500 and 3 of their 4 losses have come to teams with a losing record. I would hope they would dominate the Cards, who have a bad team and didn’t even have their starting QB. Best in the NFC? Hahaha

  14. If I was Jimmy G, I would demand a major contract extension now or sit out. He has never had more value than he does right now. San Fran screwed him over last year and wouldn’t even let him practice with the team this summer. He ought to do what Rodgers did, demand a long-term top of the market contract or refuse to player another game. If it weren’t for Jimmy G, Shannahan would probably be in the hot seat right now because they were not going to win many games with Lance at quarterback.

  15. Out played, out coached and out hustled. Interestingly its billed as a Cards home game but the stands tell a different story.

    On the plus side, Colt McCoy’s offense doesn’t seem scattered and confused. Way less false start penalties too.

  16. TheTruth says:
    November 22, 2022 at 10:34 am
    They are 1-1 against teams that currently have a record over .500 and 3 of their 4 losses have come to teams with a losing record. I would hope they would dominate the Cards, who have a bad team and didn’t even have their starting QB. Best in the NFC? Hahaha
    ___________________
    Blah blah blah blah, all I see are wins stacking. You’re dismissing the addition of CMC, and the advantage he brings especially on 3rd down conversions. So I’ll ask you what’s better, to start off hot, or to finish hot?

  17. mjchockey1 says:
    November 22, 2022 at 10:44 am
    If I was Jimmy G, I would demand a major contract extension now or sit out. He has never had more value than he does right now. San Fran screwed him over last year and wouldn’t even let him practice with the team this summer. He ought to do what Rodgers did, demand a long-term top of the market contract or refuse to player another game. If it weren’t for Jimmy G, Shannahan would probably be in the hot seat right now because they were not going to win many games with Lance at quarterback.
    __________________________
    Yea, that move is really working out for Aaron. Also, Jimmy isn’t Aaron Rodgers, and take a look at the interest he got in the off-season

  18. jimmyjohson2020 says:
    November 22, 2022 at 12:04 am
    Mr. Cheese says:
    November 21, 2022 at 11:36 pm
    9er fans do you do still want Aaron Rodgers…asking for a friend
    ————-
    Yes. Niners won’t ask Rodgers to carry them. They are far superior to pack in talent and Rodgers is more accurate and clutch than Jimmy. As a niner fan I’d take Rodgers or Brady in a heartbeat

  19. TheTruth says:
    November 22, 2022 at 10:34 am
    MortimerInMiami says:
    November 21, 2022 at 11:33 pm
    49ers are the best team in the NFC, yes its true Eagle fans.
    ————————————
    They are 1-1 against teams that currently have a record over .500 and 3 of their 4 losses have come to teams with a losing record. I would hope they would dominate the Cards, who have a bad team and didn’t even have their starting QB. Best in the NFC? Hahaha
    ————-
    They did what was expected against an inferior opponent. I’d also like to see how they do against a great opponent. One thing though: niners have had multiple playoff runs and are battle tested and would likely compete against anyone.

  20. yearofthebrian says:
    November 22, 2022 at 11:16 am
    mjchockey1 says:
    November 22, 2022 at 10:44 am
    If I was Jimmy G, I would demand a major contract extension now or sit out. He has never had more value than he does right now. San Fran screwed him over last year and wouldn’t even let him practice with the team this summer. He ought to do what Rodgers did, demand a long-term top of the market contract or refuse to player another game. If it weren’t for Jimmy G, Shannahan would probably be in the hot seat right now because they were not going to win many games with Lance at quarterback.
    __________________________
    Yea, that move is really working out for Aaron. Also, Jimmy isn’t Aaron Rodgers, and take a look at the interest he got in the off-season

    30Rate This
    ——————————————————————————————
    Yeah, how did those QB upgrades work out for the Broncos, Panthers, Commanders and Colts? Also, if off-season interest was a true assessment of ability, Matt Rhule would be chasing his second coach of the year award.

  21. Things are going to get really interesting next year for the 49ers and Jimmy G if he wins them a SB. What do you do with the rookie Lance?

  22. “9er fans do you do still want Aaron Rodgers…asking for a friend”

    Nope. Jimmy G is perfect for the Niners. The locker room loves jimmy and they allplay as a team. Rodgers would destroy the locker room. He’s a better QB than Jimmy, but he’d be bad for the team.

  23. I love this time of year…

    Holidays, football, changing seasons…

    And Niner fans declaring themselves SB winners after beating a team who had been 5-12 in their last 17 games, with a washed up 36 year old backup QB, and a team who has quit on their coach.

    It’s like the swallows returning to Capistrano.

    Certainly the best NFL team to not have won a SB in 28 years.

  24. Fun fact: The odds of any one team going to a Super Bowl is once every 16 years. The odds of winning are once every 32 years.

    Unless your team is the Bucs, Rams, or Cincinatti, the Niners have done better than your team in the last 3 years.

    And I don’t see many people declaring the Niners to be in the Superbowl, but they are one of the top teams in the NFC.

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